Different patterns of homozygous p16INK4A and p15INK4B deletions in childhood acute lymphoblastic leukemias containing distinct E2A translocations
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RAPID COMMUNICATION p16 Gene Homozygous Deletions in Acute Lymphoblastic Leukemia
The p16 protein is a cyclin inhibitor encoded by a gene located in 9p21, which may have antioncogenic properties, and is inactivated by homozygous p16 gene deletion or, less often, point mutation in several types of solid tumors often associated t o cytogenetic evidence of 9p21 deletion. We looked for homozygous deletion and point mutation of the p16 gene in acute lymphoblastic leukemia (ALL), ...
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0 VER THE PAST DECADE, significant advances have been made in understanding the molecular details of lymphopoiesis and the pathogenesis of lymphoid neoplasia. Major contributions to these advances have been made through study of Ifl-cell receptor (TCR) genes and the factors that control their ordered recombination and by investigation of nonrandom chromosomal translocations that occur in acute...
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ژورنال
عنوان ژورنال: Leukemia
سال: 1998
ISSN: 0887-6924,1476-5551
DOI: 10.1038/sj.leu.2401124